Dopamine beta Hydroxylase Antibody 0 Publications

Rabbit Polyclonal| Catalog number: 10777-1-AP

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Freight/Packing

Con: 27 μg/150 μl

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Species specificity:
human

Positive WB detected in:
HepG2 cells, HeLa cells, SH-SY5Y cells

Positive IHC detected in:
human liver cancer tissue

Positive IF detected in:
HepG2 cells, HeLa cells

Recommended dilution:
WB : 1:500-1:2000
IHC : 1:50-1:500
IF : 1:10-1:100

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
dopamine beta-hydroxylase (dopamine beta-monooxygenase)

Calculated molecular weight:
64.8 kDa

Observed molecular weight:
63 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
DBH

Synonyms
DBH, Dopamine beta Hydroxylase, Dopamine beta monooxygenase
Background

DBH(Dopamine beta-hydroxylase) belongs to the copper type II ascorbate-dependent monooxygenase family and catalyzes the oxidative hydroxylation of dopamine to norepinephrine. It is almost exclusively located in the adrenal medulla and the synaptic vesicles of postganglionic sympathetic neurons(PMID:11857564).The DBH is glycosylated (63--67 kDa) while still in the membrane(PMID:2325165) and it can form a dimer(PMID:8546710). Defects in DBH are the cause of dopamine beta-hydroxylase deficiency (DBH deficiency).


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