DDX58 Antibody 4 Publications

Rabbit Polyclonal| Catalog number: 20566-1-AP

Featured Product KD/KO validated

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Freight/Packing

Con: 77 μg/150 μl

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Species specificity:
human, mouse

Positive WB detected in:
HepG2 cells, MCF-7 cells, mouse brain tissue

Positive IP detected in:
HepG2 cells

Positive IF detected in:
HepG2 cells

Recommended dilution:
WB : 1:500-1:2000
IP : 0.5-4.0 ug for IP and 1:200-1:1000 for WB
IF : 1:10-1:100

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Immunogen:
Peptide

Full name:
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58

Calculated molecular weight:
107 kDa

Observed molecular weight:
95 kDa,100 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
DDX58

Synonyms
DDX58, DEAD box protein 58, DKFZp434J1111, DKFZp686N19181, FLJ13599, RIG 1, RIG I, RIG-I
Background

DDX58, also named as RIG-1, belongs to the helicase family. It is involved in innate immune defense against viruses. Upon interaction with intracellular dsRNA produced during viral replication, triggers a transduction cascade involving MAVS/IPS1, which results in the activation of NF-kappa-B, IRF3 and IRF7 and the induction of the expression of antiviral cytokines such as IFN-beta and RANTES (CCL5). Detects dsRNA produced from non-self dsDNA by RNA polymerase III, such as Epstein-Barr virus-encoded RNAs (EBERs). It is essential for the production of interferons in response to RNA viruses including paramyxoviruses, influenza viruses, Japanese encephalitis virus and HCV. The antibody is specific to DDX58.


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