DHCR24 Antibody 0 Publications

Mouse Monoclonal| Catalog number: 60028-1-Ig |CloneNo.: 2F6E11

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Freight/Packing

Con: 150 μg/150 μl

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Tested Applications

Applications:
ELISA
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Species specificity:
human, mouse

Recommended dilution:

Product Information


Source:
Mouse

Purification method:
Caprylic acid/ammonium sulfate precipitation

Isotype:
IgG1

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
24-dehydrocholesterol reductase

Calculated molecular weight:
60 kDa, 516aa

Observed molecular weight:

GenBank accession number:

Gene ID (NCBI):

Gene symbol
DHCR24

Synonyms
DHCR24, Diminuto/dwarf1 homolog, KIAA0018, Nbla03646, seladin 1, SELADIN1
Background

DHCR24(3-beta-hydroxysterol delta-24-reductase), a member of the flavin adenine dinucleotide (FAD)-dependent oxidoreductases, catalyzes the reduction of the delta-24 double bond of sterol intermediates during cholesterol biosynthesis.The dhcr24 expression was shown to be downregulated in brain areas affected by Alzheimer’s disease and endogenous DHCR24/seladin-1 levels are highly up-regulated upon acute oxidative stress while expression declines to very low levels upon chronic exposure(PMID:17984220).


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