DISC1-long-specific Antibody 0 Publications

Rabbit Polyclonal| Catalog number: 15500-1-AP

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Freight/Packing

Con: 60 μg/150 μl

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Species specificity:
human, mouse

Positive WB detected in:
SH-SY5Y cells, human kidney tissue, mouse brain tissue, mouse kidney tissue

Positive IP detected in:
mouse brain tissue

Positive IHC detected in:
human brain tissue

Positive IF detected in:
MDCK cells

Recommended dilution:
WB : 1:200-1:1000
IP : 0.5-4.0 ug for IP and 1:200-1:1000 for WB
IHC : 1:20-1:200
IF : 1:20-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Immunogen:
Peptide

Full name:
disrupted in schizophrenia 1

Calculated molecular weight:
95 kDa

Observed molecular weight:
60kDa, 62 kDa,75- 85 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
DISC1

Synonyms
C1orf136, DISC1, DISC1 long, disrupted in schizophrenia 1, FLJ13381, FLJ21640, FLJ25311, FLJ41105, KIAA0457, SCZD9
Background

DISC1, also named as KIAA0457, is identified as the sole gene whose ORF is truncated and cosegregates with major mental illnesses in a Scottish family. DISC1 may be implicated in psychiatric conditions in other populations than the unique Scottish family. It is involved in the regulation of multiple aspects of embryonic and adult neurogenesis. DISC1 is required for neural progenitor proliferation in the ventrical/subventrical zone during embryonic brain development and in the adult dentate gyrus of the hippocampus. It plays a role, together with PCNT, in the microtubule network formation. In WB, DISC1 has some MW such as 34kd(PMID:18620078 );75-85kd and 95-100kd(PMID:15657124). DISC1 isoforms have distinct developmental patterns of expression. This antibody is against C-terminal of DISC1, binding full length protein specifically.


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