DMXL2 Antibody 1 Publications

Rabbit Polyclonal| Catalog number: 24415-1-AP

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Freight/Packing

Con: 35 μg/150 μl

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Species specificity:
human, mouse

Positive WB detected in:
mouse brain tissue

Positive IP detected in:
mouse brain tissue

Positive IHC detected in:
human cerebellum tissue,human kidney tissue

Recommended dilution:
WB : 1:200-1:1000
IP : 0.5-4.0 ug for IP and 1:150-1:600 for WB
IHC : 1:50-1:500

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
Dmx-like 2

Calculated molecular weight:
3036aa,340 kDa

Observed molecular weight:
340 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
DMXL2

Synonyms
Dmx like 2, DmX like protein 2, DMXL2, FLJ26672, KIAA0856, Rabconnectin 3, RC3
Background

DMXL2, also named as rabconnectin-3, is a functional regulator of mammalian notch signaling with WD domains. Rabconnectin-3 is abundantly expressed in the brain where it is enriched in the synaptic vesicle fraction. Immunofluorescence and immunoelectron microscopy revealed that rabconnectin-3 was concentrated on synaptic vesicles at synapses. It may serve as a scaffold molecule for both Rab3 GEP and GAP on synaptic vesicles. In western blotting, we got 340 kDa and 104 kDa in mouse tissues. The two bands may represent different isoforms.


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