DOCK4 Antibody 0 Publications

Rabbit Polyclonal| Catalog number: 21861-1-AP

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Freight/Packing

Con: 51 μg/150 μl

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Species specificity:
human

Positive WB detected in:
HEK-293 cells

Positive IP detected in:
HeLa cells, HEK-293T cells

Positive IHC detected in:
human ovary tumor tissue, human breast cancer tissue, human ovary tumor tissue, human prostate cancer tissue, human skeletal muscle tissue

Positive IF detected in:
HeLa cells

Recommended dilution:
WB : 1:150-1:600
IP : 0.5-4.0 ug for IP and 1:500-1:1000 for WB
IHC : 1:50-1:500
IF : 1:50-1:500

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
dedicator of cytokinesis 4

Calculated molecular weight:
2011aa,230 kDa

Observed molecular weight:
225 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
DOCK4

Synonyms
dedicator of cytokinesis 4, DOCK4, FLJ34238, KIAA0716
Background

DOCK4, originally identified as a product of a gene which is deleted during tumor progression, is a member of DOCK180 family proteins. Dock4 has been found recently to be associated with several neuropsychiatric diseases, including autism, dyslexia, and schizophrenia. Multiple studies in fibroblasts then confirmed that Dock4 is capable of controlling cell migration by transducing several upstream signals, such as Wnt, platelet-derived growth factor, and RhoG, toward activation of Rac1. Mutations in this gene have been associated with ovarian, prostate, glioma, and colorectal cancers.


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