E2F1 Antibody 13 Publications

Rabbit Polyclonal| Catalog number: 12171-1-AP

Featured Product KD/KO validated

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Freight/Packing

Con: 46 μg/150 μl

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Species specificity:
human, mouse, rat, Artemia

Positive WB detected in:
mouse brain tissue, A431 cells, HeLa cells, NIH/3T3 cells

Positive IHC detected in:
human breast cancer tissue

Recommended dilution:
WB : 1:200-1:1000
IHC : 1:50-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
E2F transcription factor 1

Calculated molecular weight:
437aa,47 kDa

Observed molecular weight:
55 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
E2F1

Synonyms
E2F 1, E2F transcription factor 1, E2F1, PBR3, PRB binding protein E2F 1, RBAP 1, RBAP1, RBBP 3, RBBP3, Transcription factor E2F1
Background

Transcription factor E2F1 (E2F1), also known as RBBP3, is a transcription activator that binds DNA cooperatively with dp proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F-1 binds preferentially RB1 protein, in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent apoptosis. This antibody is a rabbit polyclonal antibody raised against the C-terminal 350 aa sequence of E2F1 protein, specifically recognizes the 47kd human E2F1 protein. The sumoylated E2F1 is bout 55 kDa.


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