EIF3D Antibody 8 Publications

Rabbit Polyclonal| Catalog number: 10219-1-AP

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Freight/Packing

Con: 20 μg/150 μl

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Species specificity:
human, mouse, yeast, rabbit

Positive WB detected in:
mouse brain tissue, A549 cells, HepG2 cells, human brain tissue, L02 cells, mouse brain tissue

Positive IHC detected in:
human breast cancer tissue

Positive IF detected in:
MCF-7 cells, HepG2 cells, Ethacrynic acid treated HepG2 cells

Recommended dilution:
WB : 1:500-1:1000
IHC : 1:20-1:200
IF : 1:20-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
eukaryotic translation initiation factor 3, subunit D

Calculated molecular weight:
66 kDa

Observed molecular weight:
66 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
EIF3D

Synonyms
eIF 3 zeta, eIF3 p66, eIF3 zeta, EIF3D, EIF3S7
Background

The mammalian translation initiation factor 3 (eIF3), is a multiprotein complex of ~600 kDa that binds to the 40 S ribosome and promotes the binding of methionyl-tRNAi and mRNA. The EIF3S7(p66) is the major RNA binding subunit in this complex. Human eIF3-p66 shares 64% sequence identity with a hypothetical Caenorhabditis elegans protein, presumably the p66 homolog. Deletion analyses of recombinant derivatives of eIF3-p66 show that the RNA-binding domain lies within an N-terminal 71-amino acid region rich in lysine and arginine.


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