HER2/ErbB2 Antibody 0 Publications

Mouse Monoclonal| Catalog number: 60311-1-Ig |CloneNo.: 1B12A7

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Freight/Packing

Con: 90 μg/150 μl

Choose size:

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Species specificity:
human

Positive IHC detected in:
human breast cancer tissue

Positive FC detected in:
HeLa cells

Recommended dilution:
IHC : 1:50-1:400

Product Information


Source:
Mouse

Purification method:
Protein A purification

Isotype:
IgG2b

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)

Calculated molecular weight:
1255aa,138 kDa

Observed molecular weight:

GenBank accession number:

Gene ID (NCBI):

Gene symbol
ERBB2

Synonyms
CD340, ERBB2, HER 2, HER 2/neu, HER2, MLN 19, MLN19, NEU, NGL, p185, p185erbB2, Proto oncogene c ErbB 2, Proto oncogene Neu, TKR1
Background

HER2, also known as ErbB2 and Neu, is a 185-kDa transmembrane glycoprotein that is a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. It has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Amplification and/or overexpression of HER2 have been reported in numerous cancers, including breast and ovarian tumors. HER2 is a therapeutic target for the treatment of breast cancer and other carcinomas.


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