EXOSC2 Antibody 0 Publications

Rabbit Polyclonal| Catalog number: 14805-1-AP

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Freight/Packing

Con: 32 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
HeLa cells, HeLa cells, HepG2 cells, Jurkat cells, MCF-7 cells

Positive IP detected in:
HeLa cells

Positive IHC detected in:
human skin cancer tissue

Positive IF detected in:
MCF-7 cells

Recommended dilution:
WB : 1:500-1:2000
IP : 0.5-4.0 ug for IP and 1:500-1:2000 for WB
IHC : 1:20-1:200
IF : 1:20-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
exosome component 2

Calculated molecular weight:
33 kDa

Observed molecular weight:
30-33 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
EXOSC2

Synonyms
EXOSC2, exosome component 2, hRrp4p, p7, RRP4, Rrp4p
Background

In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snoRNA and snRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs [PMID:15346807]. EXOSC2 is a non-catalytic component of the RNA exosome complex that has 3'->5' exoribonuclease activity and involves in a multitude of cellular RNA processing and degradation events [PMID: 17545563].


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