FAS/CD95 Antibody 21 Publications

Rabbit Polyclonal| Catalog number: 13098-1-AP

Featured Product KD/KO validated

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Freight/Packing

Con: 70 μg/150 μl

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Species specificity:
human, monkey, mouse, pig, rat, sheep

Positive WB detected in:
HeLa cells,Jurkat cells

Positive IP detected in:
HeLa cells

Positive IHC detected in:
human prostate cancer tissue, human colon cancer tissue, human prostate cancer tissue

Positive FC detected in:
Jurkat cells

Recommended dilution:
WB : 1:500-1:2000
IP : 0.5-4.0 ug for IP and 1:500-1:1000 for WB
IHC : 1:50-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
Fas (TNF receptor superfamily, member 6)

Calculated molecular weight:
35-38 kDa

Observed molecular weight:
38-45 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
FAS

Synonyms
ALPS1A, APO 1, Apo 1 antigen, APT1, CD95, FAS, FAS1, FASLG receptor, FASTM, TNFRSF6
Background

Fas (CD95/APO-1) is a transmembrane glycoprotein belonging to the tumor necrosis factor (TNF) receptor superfamily. It can mediates apoptosis by ligation with an agonistic anti-Fas antibody or Fas ligand. Stimulation of Fas results in the aggregation of its intracellular death domains, leading to the formation of the death-inducing signaling complex (DISC). FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The molecular mass of native Fas is 38 kDa, the high molecular weight form (40-55 kDa) of Fas is due to glycosylation.


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