FOXO3A Antibody 7 Publications

Rabbit Polyclonal| Catalog number: 10849-1-AP

Featured Product KD/KO validated

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Freight/Packing

Con: 53 μg/150 μl

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Species specificity:
human, mouse, rat, pig

Positive WB detected in:
HEK-293 cells,HeLa cells, PC-3 cells

Positive IHC detected in:
human breast cancer tissue, human breast cancer tissue, human prostate cancer tissue

Positive IF detected in:
HeLa cells

Recommended dilution:
WB : 1:500-1:1000
IHC : 1:50-1:200
IF : 1:10-1:100

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
forkhead box O3

Calculated molecular weight:
673aa,71 kDa

Observed molecular weight:
72-97 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
FOXO3

Synonyms
AF6q21, AF6q21 protein, DKFZp781A0677, FKHRL1, FKHRL1P2, forkhead box O3, Forkhead box protein O3, FOXO2, FOXO3, FOXO3A
Background

In mammalian cells, FoxO factors act as potent transcriptional activators that upregulate the expression of programs of genes involved in stress resistance, cell cycle arrest, differentiation, apoptosis, autophagy, and metabolism. FOXO3 has a key role in the maintenance of adult neural and hematopoietic stem cells. It also associates with extreme longevity in humans and regulates the homeostasis of adult stem cell pools in mammals, which may contribute to longevity. Phosphorylation inhibits FOXO3 nuclear translocation that is essential for its regulation and function. The calculated molecular weight of FOXO3 is 71 kDa,but some experiments analysis using a FOXO3a specific antibody showed the expression of a 90 kDa fulllength FOXO3a protein (Full) and a 40 kDa processed FOXO3a product (Short). 90 kDa FOXO3a protein is a phosphorylated via activation of PI3K (phosphatidylinositol 3-kinase) and Akt after insulin stimulation, and translocate from the nucleus to the cytoplasm. (PMID: 19427386)


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