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FOXO4 Antibody 4 Publications

Rabbit Polyclonal| Catalog number: 21535-1-AP

Featured Product KD/KO validated

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Con: 59 μg/150 μl

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Tested Applications

Applications:
WB, IHC, ELISA
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Images See all

FOXO4 Antibody WB mouse heart tissue 21535-1-AP

mouse heart tissue were subjected to SDS PAGE followed by western blot with 21535-1-AP(FOXO4 antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours

FOXO4 Antibody IHC human kidney tissue 21535-1-AP

Immunohistochemical analysis of paraffin-embedded human kidney using 21535-1-AP(FOXO4 antibody) at dilution of 1:100 (under 10x lens)

FOXO4 Antibody IHC human kidney tissue 21535-1-AP

Immunohistochemical analysis of paraffin-embedded human kidney using 21535-1-AP(FOXO4 antibody) at dilution of 1:100 (under 40x lens)

Species specificity:
human, mouse, rat, DOG
Positive WB detected in:
mouse heart tissue, mouse uterus tissue
Positive IHC detected in:
human kidney tissue

Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0
Recommended dilution:
WB : 1:500-1:3000
IHC : 1:20-1:200
Sample-dependent, check data in Validation tab

Protocols

Product-specific protocols

Standard Protocols

Product Information

Source:
Rabbit
Purification method:
Antigen affinity purification
Isotype:
IgG
Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information

Immunogen:
FOXO4 fusion protein Ag16169
Full name:
forkhead box O4
Calculated molecular weight:
505aa,54 kDa
Observed molecular weight:
65 kDa
GenBank accession number:
BC106761
Gene ID (NCBI):
4303
Gene symbol
FOXO4
Synonyms
AFX, AFX1, forkhead box O4, Forkhead box protein O4, FOXO4, MLLT7

Background

FOXO4, also named as AFX, AFX1 and MLLT7, is a transcription factor which involved in the regulation of the insulin signaling pathway. It binds to insulin-response elements (IREs) and can activate transcription of IGFBP1.FOXO down-regulates expression of HIF1A and suppresses hypoxia-induced transcriptional activation of HIF1A-modulated genes. It is involved in negative regulation of the cell cycle. A chromosomal aberration involving FOXO4 is found in acute leukemias. The antibody can recognize isoform 1 and isoform Zeta of FOXO4.


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