FOXO4 Antibody 2 Publications

Rabbit Polyclonal| Catalog number: 21535-1-AP

Featured Product KD/KO validated

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Con: 59 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
mouse heart tissue, mouse uterus tissue

Positive IHC detected in:
human kidney tissue

Recommended dilution:
WB : 1:500-1:3000
IHC : 1:20-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
forkhead box O4

Calculated molecular weight:
505aa,54 kDa

Observed molecular weight:
65kd

GenBank accession number:

Gene ID (NCBI):

Gene symbol
FOXO4

Synonyms
AFX, AFX1, forkhead box O4, Forkhead box protein O4, FOXO4, MLLT7
Background

FOXO4, also named as AFX, AFX1 and MLLT7, is a transcription factor which involved in the regulation of the insulin signaling pathway. It binds to insulin-response elements (IREs) and can activate transcription of IGFBP1.FOXO down-regulates expression of HIF1A and suppresses hypoxia-induced transcriptional activation of HIF1A-modulated genes. It is involved in negative regulation of the cell cycle. A chromosomal aberration involving FOXO4 is found in acute leukemias. The antiboay can recognize isoform 1 and isoform Zeta of FOXO4.


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