GAD65 Antibody 2 Publications

Rabbit Polyclonal| Catalog number: 20746-1-AP

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Freight/Packing

Con: 82 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
mouse brain tissue

Positive IP detected in:
mouse brain tissue

Positive IF detected in:
HeLa cells

Recommended dilution:
WB : 1:500-1:3000
IP : 0.5-4.0 ug for IP and 1:500-1:2000 for WB
IF : 1:10-1:100

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Immunogen:
Peptide

Full name:
glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)

Calculated molecular weight:
65 kDa

Observed molecular weight:
65 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
GAD2

Synonyms
GAD 65, GAD2, GAD65, Glutamate decarboxylase 2
Background

GAD2, also named as GAD65, belongs to the group II decarboxylase family. GAD2 catalyzes the production of GABA. It is responsible for the synthesis of the essential neurotransmitter gamma-aminobutyric acid (GABA) from L-glutamic acid. GAD2 is expressed in nervous and endocrine systems and are thought to be involved in synaptic transmission and insulin secretion. Autoantibodies against GAD2 may serve as markers for type I diabetes. Many individuals suffering from an adult onset disorder known as Stiff Person Syndrome (SPS) also express autoantibodies to GAD2. The antibody is specific to GAD2.


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