Galectin-3 Antibody 6 Publications

Mouse Monoclonal| Catalog number: 60207-1-Ig |CloneNo.: 1C1B2

Featured Product KD/KO validated

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Freight/Packing

Con: 125 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
HeLa cells,HSCT6 cells, HeLa cells

Positive IHC detected in:
human thyroid cancer tissue, human colon tissue, human thyroid cancer tissue

Positive IF detected in:
MCF-7 cells

Recommended dilution:
WB : 1:1000-1:5000
IHC : 1:50-1:200
IF : 1:20-1:200

Product Information


Source:
Mouse

Purification method:
Protein A purification

Isotype:
IgG2b

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
lectin, galactoside-binding, soluble, 3

Calculated molecular weight:
26 kDa

Observed molecular weight:
31 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
LGALS3

Synonyms
35 kDa lectin, CBP 35, CBP35, Gal 3, GAL3, Galactose specific lectin 3, Galactoside binding protein, GALBP, Galectin 3, Galectin-3, GALIG, IgE binding protein, L 31, Laminin binding protein, Lectin L 29, LGALS2, LGALS3, Mac 2 antigen, MAC2
Background

Galectins are a family of animal lectins defined by shared characteristic amino-acid sequences and affinity for β-galactose-containing oligosac-charides (PMID: 8063692). Galectin-3, a 31-kDa member of the β-galactoside-binding proteins, contains one carbohydrate recognition domain (CRD) and a proline- and glycine-rich N-terminal domain through which is able to form oligomers (PMID: 14758078). Galectin-3 is widely expressed in many normal tissues and a variety of tumors. It is found intracellularly in nucleus and cytoplasm or secreted outside of cell, being present on the cell surface or in the extracellular space (PMID: 16478649). Galectin-3 is involved in various biological processes including cell growth, adhesion, differentiation, apoptosis, angiogenesis, immune response, neoplastic transformation and metastasis (PMID: 16478649; 14758078).


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