GCK Antibody 5 Publications

Rabbit Polyclonal| Catalog number: 19666-1-AP

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Freight/Packing

Con: 26 μg/150 μl

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Species specificity:
mouse, rat, human

Positive WB detected in:
mouse liver tissue, mouse pancreas tissue

Positive IP detected in:
mouse liver tissue

Positive IHC detected in:
human liver tissue

Recommended dilution:
WB : 1:500-1:1000
IP : 0.5-4.0 ug for IP and 1:500-1:1000 for WB
IHC : 1:100-1:400

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
glucokinase (hexokinase 4)

Calculated molecular weight:
52 kDa

Observed molecular weight:
50-52 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
GCK

Synonyms
GCK, GK, GLK, Glucokinase, glucokinase (hexokinase 4), Hexokinase 4, Hexokinase D, Hexokinase type IV, HHF3, HK IV, HK4, HKIV, HXKP, MODY2
Background

Glucokinase (GCK) is a structurally and functionally unique member of hexokinase family. It is expressed only in mammalian liver and pancreatic islet beta cells. Because of its unique functional characteristics, the enzyme plays an important regulatory role in glucose metabolism.The rate of glucose metabolism in liver and pancreas is a function of the activity of the enzyme(PMID:1740341). Moreover, GCK has been found to have relationship with diabetes. Defects in GCK are the cause of maturity-onset diabetes of the young type 2 (MODY2) and familial hyperinsulinemic hypoglycemia type 3 (HHF3). It has 3 isoforms produced by alternative splicing with the same molecular mass of 52 kDa.


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