Connexin-43 Antibody 7 Publications

Rabbit Polyclonal| Catalog number: 15386-1-AP

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Freight/Packing

Con: 50 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
HeLa cells

Positive IP detected in:
mouse heart tissue

Positive IHC detected in:
mouse heart tissue, human heart tissue, mouse heart tissue

Positive IF detected in:
HeLa cells,mouse heart tissue

Positive FC detected in:
Jurkat cells

Recommended dilution:
WB : 1:500-1:2000
IP : 0.5-4.0 ug for IP and 1:500-1:1000 for WB
IHC : 1:50-1:200
IF : 1:50-1:500

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
gap junction protein, alpha 1, 43kDa

Calculated molecular weight:
43 kDa

Observed molecular weight:
43-47 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
GJA1

Synonyms
Connexin-43, CX43, DFNB38, Gap junction alpha 1 protein, GJA1, GJAL, ODDD
Background

Connexin-43 (Cx43, also known as gap junction alpha-1), a member of connexin family, plays essential roles in gap junction communication that facilitates direct communication among adjacent cells (PMID: 12270943). Usually, six connexin proteins oligomerize into a hemi-channel or connexon during intercellular channel formation (PMID: 12270943). Mutations of Cx43 may cause a series of diseases such as oculodentodigital dysplasia (ODDD), syndactyly 3 (SDTY3), hypoplastic left heart syndrome 1 (HLHS1) and so on (PMID: 18161618, 1472936, 1147490).


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