HSP90 Antibody 2 Publications

Mouse Monoclonal| Catalog number: 60318-1-Ig |CloneNo.: 3F11C1

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Con: 150 μg/150 μl

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Species specificity:
human, mouse, rat, pig

Positive WB detected in:
HeLa cells, Y79 cells

Positive IHC detected in:
human ovary tumor tissue

Positive FC detected in:
K-562 cells

Recommended dilution:
WB : 1:1000-1:8000
IHC : 1:50-1:500

Product Information


Source:
Mouse

Purification method:
Protein A purification

Isotype:
IgG2a

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
heat shock protein 90kDa alpha (cytosolic), class A member 1

Calculated molecular weight:
853aa,90 kDa

Observed molecular weight:
85-90 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
HSP90AA1

Synonyms
FLJ31884, Heat shock 86 kDa, HSP 86, HSP86, Hsp89, HSP89A, HSP90, HSP90A, HSP90AA1, HSP90N, HSPC1, HSPCA, HSPCAL1, HSPCAL4, HSPN, LAP2
Background

HSP90, encoded by HSP90AA1, is a constitutively and ubiquitously expressed molecular chaperone that is crucial for the stability and function of many proteins. HSP90 provides chaperoning activity for client proteins; many of them are members of oncogenic pathways, indicating its implication in tumor malignancy. HSP90 mainly resides in the cytosol, while it can also be released to the extracellular space. Secreted Hsp90 is a C-terminal truncated form. It has been reported that the level of plasma Hsp90 is positively correlated with tumor malignancy in clinical cancer patients, and can be a promising diagnostic marker for tumor malignancy in clinical application.


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