IDH1 Antibody 0 Publications

Rabbit Polyclonal| Catalog number: 23309-1-AP

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Freight/Packing

Con: 71 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
HepG2 cells, DU 145 cells, HEK-293 cells, HepG2 cells, MCF-7 cells, mouse liver tissue, NIH/3T3 cells

Positive IHC detected in:
human gliomas tissue, human gliomas tissue, human liver cancer tissue

Recommended dilution:
WB : 1:500-1:2000
IHC : 1:20-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
isocitrate dehydrogenase 1 (NADP+), soluble

Calculated molecular weight:
414aa,47 kDa

Observed molecular weight:
46kd

GenBank accession number:

Gene ID (NCBI):

Gene symbol
IDH1

Synonyms
IDCD, IDH, IDH1, IDP, IDPC, NADP(+) specific ICDH, Oxalosuccinate decarboxylase, PICD
Background

IDH1, also named as PICD and IDP, belongs to the isocitrate and isopropylmalate dehydrogenases family. It is a common feature of a major subset of primary human brain cancers. Its subunit structure is homodimer(PMID:15173171).IDH1 mutation is always heterozygotic and IDH1 functions as a dimer, theoretically there will be 25% each wild type and mutant homo-dimers and 50% hetero-dimers present in the tumor cells(PMID:21079649 ). This antibody is specific to IDH1.


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