IFITM2-specific Antibody 3 Publications

Mouse Monoclonal| Catalog number: 66137-1-Ig |CloneNo.: 3D5F7

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Freight/Packing

Con: 132 μg/150 μl

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Species specificity:
human

Positive WB detected in:
HepG2 cells, recombinant protein

Positive FC detected in:
HeLa cells

Recommended dilution:
WB : 1:500-1:2000

Product Information


Source:
Mouse

Purification method:
Protein G purification

Isotype:
IgG1

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Immunogen:
Fusion Protein

Full name:
interferon induced transmembrane protein 2 (1-8D)

Calculated molecular weight:

Observed molecular weight:
15 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
IFITM2

Synonyms
DSPA2c, IFITM2
Background

IFITM2, also named as 1-8D, belongs to the CD225 family. It is an IFN-induced antiviral protein that mediates cellular innate immunity to at least three major human pathogens, namely influenza A H1N1 virus, West Nile virus (WNV), and dengue virus (WNV), by inhibiting the early step(s) of replication. IFITM2 induces cell cycle arrest and mediates apoptosis by caspase activation and in p53-independent manner. It is overexpressed in colon carcinoma. IFITM2 is a novel pro-apoptotic gene that will provide new insights into the regulated cellular pathways to death.(PMID:19544527) This antibody is specific to IFTIM2.


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