|Positive WB detected in||HepG2 cells, recombinant protein|
|Positive FC detected in||HeLa cells|
|Western Blot (WB)||WB : 1:500-1:2000|
|Sample-dependent, check data in validation data gallery|
The immunogen of 66137-1-Ig is IFITM2-specific Fusion Protein expressed in E. coli.
|Host / Isotype||Mouse / IgG1|
|Full Name||interferon induced transmembrane protein 2 (1-8D)|
|Observed molecular weight||15 kDa|
|GenBank accession number||NM_006435|
|Gene ID (NCBI)||10581|
|Purification Method||Protein G purification|
|Storage Buffer||PBS with 0.02% sodium azide and 50% glycerol pH 7.3.|
|Storage Conditions||Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.|
IFITM2, also named as 1-8D, belongs to the CD225 family. It is an IFN-induced antiviral protein that mediates cellular innate immunity to at least three major human pathogens, namely influenza A H1N1 virus, West Nile virus (WNV), and dengue virus (WNV), by inhibiting the early step(s) of replication. IFITM2 induces cell cycle arrest and mediates apoptosis by caspase activation and in p53-independent manner. It is overexpressed in colon carcinoma. IFITM2 is a novel pro-apoptotic gene that will provide new insights into the regulated cellular pathways to death.(PMID:19544527) This antibody is specific to IFTIM2.
Nat Chem Biol
IFITM3 directly engages and shuttles incoming virus particles to lysosomes.
A CRISPR screen for factors regulating SAMHD1 degradation identifies IFITMs as potent inhibitors of lentiviral particle delivery.
IFITM3-containing exosome as a novel mediator for anti-viral response in dengue virus infection.
IFITM proteins inhibit HIV-1 protein synthesis.
p53 promotes ZDHHC1-mediated IFITM3 palmitoylation to inhibit Japanese encephalitis virus replication.