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Recombinant human IFN alpha 2A (Cat.NO. HZ-1066) inhibits the growth of TF-1 cell line (human erythroleukemic cell line) in a dose-dependent manner (blue curve, refer to bottom X-left Y). The activity of human IFN alpha 2A (100 ng/mL HZ-1066) is neutralized by mouse anti-human IFN alpha 2A monoclonal antibody 69008-1-Ig at serial dose (red curve, refer to top X-right Y). The ND50 is typically 300-500 ng/mL.
Interferon alpha 2 is a type 1 interferon. Interferon alpha 2 is secreted by virus-infected cells and inhibits other cells from further infection. Recombinant human interferon alpha 2 has been approved for therapeutic application in a range of human oncological and viral diseases. Three Interferon alpha 2 subvariants (2A, 2B, 2C) differ by only one or two amino acids at positions 23 and/or 34 of the mature protein (PMID: 25982860; 10672347; 1694761).
This antibody is used to Block/Neutralize Interferon alpha 2 protein.