NeutraKine™ IL-6 Monoclonal antibody
NeutraKine™ IL-6 Monoclonal Antibody for FC, IHC, Neutralization,ELISA
Host / Isotype
Mouse / IgG1
Neutralization, IHC, FC,ELISA
Cat no : 69001-1-Ig
|Neutralization||Measured by its ability to neutralize IL-6 induced proliferation of hybridoma. The half neutralization dose (ND50) is typically 3-15 ng/mL in the presence of 1 ng/mL human IL-6.|
69001-1-Ig targets NeutraKine™ IL-6 in Neutralization, IHC, FC,ELISA applications and shows reactivity with Human samples.
|Host / Isotype||Mouse / IgG1|
|Immunogen||human Humankine IL-6 protein HZ-1019|
|Full Name||interleukin 6 (interferon, beta 2)|
|Gene ID (NCBI)||3569|
|Purification Method||Protein A purification|
|Storage Buffer||Sterile PBS.|
|Reconstitution||This product was lyophilized from a 0.2 μm filtered solution in PBS. Reconstitute at 1.0 mg/mL in sterile H2O before use.|
|Stability and Storage||Lyophilized antibodies are stable for 1 year from the date of receipt if stored between (-20°C) and (-80°C). Upon reconstitution we recommend that the solution can be stored at (4°C) for short term or at (-20°C) to (-80°C) for long term. Repeated freeze thaw cycles should be avoided with reconstituted products.|
Interleukin-6 (IL-6) is an interleukin that acts as both a pro-inflammatory and anti-inflammatory cytokine. IL-6 protein is secreted by a variety of cell types including T cells and macrophages as phosphorylated and variably glycosylated molecule. IL-6 plays an essential role in the final differentiation of B-cells into Ig-secreting cells involved in lymphocyte and monocyte differentiation. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. IL-6 is also considered a myokine, a cytokine produced from muscle, and is elevated in response to muscle contraction. IL-6 has been shown to interact with interleukin-6 receptor and glycoprotein 130. Additionally, IL-6 is involved in hematopoiesis, bone metabolism, and cancer progression, and has been defined an essential role in directing transition from innate to acquired immunity.
This antibody is used to Block/Neutralize IL6 protein.
|Product Specific Protocols|
|Neutralization protocol of NeutraKine™ IL-6 antibody 69001-1-Ig||Download protocol|
|IHC protocol for NeutraKine™ IL-6 antibody 69001-1-Ig||Download protocol|
|FC protocol for NeutraKine™ IL-6 antibody 69001-1-Ig||Download protocol|
|Click here to view our Standard Protocols|