IL-10 Antibody 1 Publications

Mouse Monoclonal| Catalog number: 60269-1-Ig |CloneNo.: 8E4B6

  • Print page
  • Download PDF

Be the first to review this product


-_-

Freight/Packing

Con: 85 μg/150 μl

Choose size:

Please visit your regions distributor:


Species specificity:
human

Positive WB detected in:
ag14870, Recombinant protein, Transfected HEK-293 cells

Positive IHC detected in:
human pancreas cancer tissue

Recommended dilution:
WB : 1:2000-1:20000
IHC : 1:50-1:500

Product Information


Source:
Mouse

Purification method:
Protein A purification

Isotype:
IgG2b

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
interleukin 10

Calculated molecular weight:
21 kDa

Observed molecular weight:
22 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
IL10

Synonyms
CSIF, IL 10, IL10, IL-10, IL10A, interleukin 10, TGIF
Background

Interleukin (IL)-10 is an anti-inflammatory cytokine, produced by T helper (Th) cells, macrophages, monocytes, and B cells, that plays a crucial role in preventing inflammatory and autoimmune pathologies. It downregulates the expression of Th1 cytokines, MHC class II antigens, and co-stimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. IL-10 can block NF-κB activity, and is involved in the regulation of the JAK-STAT signaling pathway. IL-10, along with its receptors, describes an important role in pathogenesis of various diseases, including infectious, inflammatory, autoimmune diseases. IL-10 mutations are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis.


Back
to top