IL-17 Antibody 10 Publications

Rabbit Polyclonal| Catalog number: 13082-1-AP

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Freight/Packing

Con: 51 μg/150 μl

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Species specificity:
human, mouse

Positive WB detected in:
U-937 cells,Transfected HEK-293 cells, human testis tissue

Positive IHC detected in:
human colon cancer tissue, human colon cancer tissue, human prostate cancer tissue

Recommended dilution:
WB : 1:500-1:1000
IHC : 1:50-1:500

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
interleukin 17A

Calculated molecular weight:
155aa,18 kDa

Observed molecular weight:

GenBank accession number:

Gene ID (NCBI):

Gene symbol
IL17A

Synonyms
CTLA 8, CTLA8, IL 17, IL 17A, IL17, IL-17, IL17A, interleukin 17A
Background

IL17A, also named as IL-17, is a proinflammatory cytokine. IL-17, synthesized only by memory T cells and natural killer cells, has pleiotropic effects, mainly in the recruitment and activation of neutrophils. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. The IL-17 receptor is a type I transmembrane protein, that is widely expressed on epithelial cells, fibroblasts, B and T cells, and monocytic cells. In psoriatic skin lesions, both Th17 cells and their downstream effector molecules, e.g. IL-17 and IL-22, are highly increased. This antibody got 32-35 kDa band in western blot, maybe due to homodimer formation and differential glycosylations.


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