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IL-17 Antibody 2 Publications

Mouse Monoclonal| Catalog number: 66148-1-Ig |CloneNo.: 1B3D5

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Con: 119 μg/150 μl

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Tested Applications
Applications:
ELISA, WB, FC
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66148-1-Ig;U-937 cells

U-937 cells were subjected to SDS PAGE followed by western blot with 66148-1-Ig(IL-17 antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours

66148-1-Ig;Jurkat cells

1X10^6 Jurkat cells were stained with 0.2ug IL-17 antibody (66148-1-Ig, red) and control antibody (blue). Fixed with 90% MeOH blocked with 3% BSA (30 min). Alexa Fluor 488-congugated AffiniPure Goat Anti-Mouse IgG(H+L) with dilution 1:1000.

Species specificity:
human
Positive WB detected in:
U-937 cells, Jurkat cells, Raji cells
Positive FC detected in:
Jurkat cells
Recommended dilution:
WB : 1:500-1:1000

Product Information

Source:
Mouse
Purification method:
Protein G purification
Isotype:
IgG1
Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information

Immunogen:
IL-17 fusion protein ag3733
Full name:
interleukin 17A
Calculated molecular weight:
155aa,18 kDa
Observed molecular weight:
18 kDa
GenBank accession number:
BC067505
Gene ID (NCBI):
3605
Gene symbol
IL17A
Synonyms
CTLA 8, CTLA8, IL 17, IL 17A, IL17, IL-17, IL17A, interleukin 17A
Background

IL17A, also named as IL-17, is a proinflammatory cytokine. IL-17, synthesized only by memory T cells and natural killer cells, has pleiotropic effects, mainly in the recruitment and activation of neutrophils. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. The IL-17 receptor is a type I transmembrane protein, that is widely expressed on epithelial cells, fibroblasts, B and T cells, and monocytic cells. In psoriatic skin lesions, both Th17 cells and their downstream effector molecules, e.g. IL-17 and IL-22, are highly increased.


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