|Positive WB detected in||mouse brain tissue, multi-cells|
|Positive IHC detected in||human lung cancer tissue, human heart tissue|
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0
|Western Blot (WB)||WB : 1:500-1:2000|
|Immunohistochemistry (IHC)||IHC : 1:50-1:500|
|Sample-dependent, check data in validation data gallery|
11920-1-AP targets ST2 in WB, IHC, IF, ELISA applications and shows reactivity with human, mouse, rat samples.
|Tested Reactivity||human, mouse, rat|
|Cited Reactivity||human, mouse, rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||ST2 fusion protein Ag2555|
|Full Name||interleukin 1 receptor-like 1|
|Calculated molecular weight||63 kDa, 37 kDa, 30 kDa|
|Observed molecular weight||30 kDa, 40 kDa|
|GenBank accession number||BC030975|
|Gene ID (NCBI)||9173|
|Purification Method||Antigen affinity purification|
|Storage Buffer||PBS with 0.02% sodium azide and 50% glycerol pH 7.3.|
|Storage Conditions||Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.|
Protein ST2, also known as IL1RL1, is a member of the interleukin 1 receptor family. The gene of ST2 encodes three splice variants: a soluble secreted form, a transmembrane form and a form of undetermined localization.This antibody recognizes at least 80kd, 40kd and 30kd forms in different tissues and cells.
Interleukin-33 prevents the development of autoimmune diabetes in NOD mice.
J Mol Cell Cardiol
Yin-Yang 1 transcription factor modulates ST2 expression during adverse cardiac remodeling post-myocardial infarction.
Helicobacter pylori Induces IL-33 Production and Recruits ST-2 to Lipid Rafts to Exacerbate Inflammation.
Circ Heart Fail
Pulmonary Production of Soluble ST2 in Heart Failure.
Med Sci Monit
Downregulated miR-524-5p Participates in the Tumor Microenvironment of Ameloblastoma by Targeting the Interleukin-33 (IL-33)/Suppression of Tumorigenicity 2 (ST2) Axis.
Clin Exp Dermatol
Interleukin-33 affects cytokine production by keratinocytes in vitiligo.