CD41/Integrin alpha 2b Antibody 0 Publications

Rabbit Polyclonal| Catalog number: 24552-1-AP

  • Print page
  • Download PDF

-_-

Freight/Packing

Con: 68 μg/150 μl

Choose size:

Please visit your regions distributor:


Species specificity:
human, rat, mouse

Positive WB detected in:
human blood tissue, rat blood tissue

Positive IP detected in:
human plasma tissue

Positive IHC detected in:
human spleen tissue, mouse spleen tissue

Recommended dilution:
WB : 1:1000-1:6000
IP : 0.5-4.0 ug for IP and 1:1000-1:4000 for WB
IHC : 1:20-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)

Calculated molecular weight:
1039aa,113 kDa

Observed molecular weight:
125 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
ITGA2B

Synonyms
CD41, CD41B, GP2B, GPalpha IIb, GPIIb, GTA, HPA3, Integrin alpha IIb, ITGA2B, ITGAB
Background

The integrins are a superfamily of cell adhesion receptors that bind to extracellular matrix ligands, cell-surface ligands, and soluble ligands (PMID: 17543136). They are transmembrane αβ heterodimers and at least 24 distinct integrin heterodimers are formed by the combination of 18 α and eight β known subunits (PMID: 17543136; 20029421). In addition to mediating cell adhesion, integrins also play important roles in modulating signal transduction pathways that control cellular responses including migration, proliferation, differentiation, and apoptosis (PMID:19118207). Integrin alpha-IIb (ITGA2B, CD41) is expressed on platelets, megakaryocytes and some hematopoietic progenitor cells (PMID: 11934866). This protein undergoes post-translational cleavage to yield disulfide linked light (25 kDa) and heavy (125 kDa) chains which join with integrin beta3 (CD61) to form a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrin alpha-IIb/beta-3 is crucial for platelet aggregation through binding of soluble fibrinogen.


Back
to top