Integrin alpha-3 Antibody 0 Publications

Rabbit Polyclonal| Catalog number: 21992-1-AP

Featured Product KD/KO validated

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Freight/Packing

Con: 42 μg/150 μl

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Species specificity:
human

Positive WB detected in:
PC-3 cells, A549 cells

Positive IP detected in:
PC-3 cells

Positive IF detected in:
A549 cells

Positive FC detected in:
PC-3 cells

Recommended dilution:
WB : 1:500-1:1000
IP : 0.5-4.0 ug for IP and 1:500-1:1000 for WB
IF : 1:20-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)

Calculated molecular weight:
1066aa,119 kDa

Observed molecular weight:
120 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
ITGA3

Synonyms
CD49C, FLJ34631, FLJ34704, FRP 2, Galactoprotein B3, GAP B3, GAPB3, Integrin alpha 3, ITGA3, MSK18, VCA 2, VL3A, VLA 3 subunit alpha, VLA3a
Background

ITGA3, also named as MSK18, CD49c, GAPB3 and FRP-2, belongs to the integrin alpha chain family. It is a receptor for fibronectin, laminin, collagen, epiligrin, thrombospondin and CSPG4. ITGA3 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration. ITGA3 is highly concentrated in epithelial cells where it strongly adheres to Laminin-5 and Laminin-5 induced rapid adhesion can be blocked by antibodies against the alpha-3 integrin subunit. It can be cleaved into heavy chain(840aa) and light chain(176aa). This antibody can recognize the heavy chain.


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