Integrin beta-3 Antibody 4 Publications

Rabbit Polyclonal| Catalog number: 18309-1-AP

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Freight/Packing

Con: 23 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
mouse spleen tissue

Positive IP detected in:
mouse spleen tissue

Recommended dilution:
WB : 1:500-1:2000
IP : 0.5-4.0 ug for IP and 1:200-1:1000 for WB

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Immunogen:
Peptide

Full name:
integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)

Calculated molecular weight:
87 kDa

Observed molecular weight:
100 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
ITGB3

Synonyms
CD61, GP3A, GPIIIa, Integrin beta 3, Integrin beta-3, ITGB3
Background

CD61, also named as ITGB3 and GPIIIa, is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. CD61 recognize the sequence R-G-D in a wide array of ligands and the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation CD61 brings about platelet/platelet interaction through binding of soluble fibrinogen which leads to rapid platelet aggregation which physically plugs ruptured endothelial surface. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. Human CD61 has a calculated molecular weight of 87 kDa. As a result of glycosylation, the apparent molecular mass of CD61 is approximately 90-110 kDa.


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