Integrin beta-4 Antibody 1 Publications

Rabbit Polyclonal| Catalog number: 21738-1-AP

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Freight/Packing

Con: 39 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
MCF7 cells, A431 cells, A549 cells

Positive IP detected in:
HeLa cells

Positive IHC detected in:
human pancreas cancer tissue, human breast cancer tissue,

Positive FC detected in:
HeLa cells

Recommended dilution:
WB : 1:500-1:3000
IP : 0.5-4.0 ug for IP and 1:500-1:1000 for WB
IHC : 1:20-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
integrin, beta 4

Calculated molecular weight:
1752aa,195 kDa

Observed molecular weight:
194-202 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
ITGB4

Synonyms
CD104, GP150, Integrin beta 4, integrin, beta 4, ITGB4
Background

Integrins are cell adhesion receptors that are heterodimers composed of non-covalently associated alpha and beta subunits. Integrin beta-4 is predominantly expressed in squamous epithelial cells, endothelial cells, immature thymocytes, Schwann cells, and fibroblasts of the peripheral nervous system (PMID: 28084395). Integrin beta-4 pairs with alpha-6, and the heterodimeric integrin alpha-6/beta-4 is a receptor for laminin. Integrin alpha-6/beta-4 plays a critical structural role in the hemidesmosome of epithelial cells, and also plays a role in the invasive and metastatic phenotype of various cancers.


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