Cytokeratin 18 Antibody 0 Publications

Rabbit Polyclonal| Catalog number: 18708-1-AP

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Freight/Packing

Con: 40 μg/150 μl

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Species specificity:
human

Positive WB detected in:
A431 cells, COLO 320 cells, HepG2 cells

Positive IP detected in:
A431 cells

Positive IHC detected in:
human renal cell carcinoma tissue, human breast cancer tissue, human colon cancer tissue, human endometrial cancer tissue, human kidney tissue, human liver tissue, human nephroblastoma tissue, human ovary tumor tissue, human skin cancer tissue

Positive IF detected in:
HepG2 cells

Recommended dilution:
WB : 1:500-1:2000
IP : 0.5-4.0 ug for IP and 1:500-1:1000 for WB
IHC : 1:200-1:800
IF : 1:50-1:500

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Immunogen:
Peptide

Full name:
keratin 18

Calculated molecular weight:
48 kDa

Observed molecular weight:
48 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
KRT18

Synonyms
CK 18, CYK18, Cytokeratin 18, K18, keratin 18, KRT18
Background

Keratins are a large family of proteins that form the intermediate filament cytoskeleton of epithelial cells, which are classified into two major sequence types. Type I keratins are a group of acidic intermediate filament proteins, including K9–K23, and the hair keratins Ha1–Ha8. Type II keratins are the basic or neutral courterparts to the acidic type I keratins, including K1–K8, and the hair keratins, Hb1–Hb6. KRT18, also named as CYK18, PIG46 and K18, is the most commonly found members of the intermediate filament gene family. KRT18 is a type I keratin which is found primarily in non squamous epithelia and is present in a majority of adenocarcinomas and ductal carcinomas but not in squamous cell carcinomas. This antibody is specifically agianst KRT18.


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