LDLR Antibody 0 Publications

Mouse Monoclonal| Catalog number: 66414-1-Ig |CloneNo.: 1A2A3

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Freight/Packing

Con: 150 μg/150 μl

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Species specificity:
human

Positive WB detected in:
HeLa cells, HEK-293 cells, Jurkat cells

Positive IHC detected in:
human liver tissue

Recommended dilution:
WB : 1:1000-1:8000
IHC : 1:50-1:500

Product Information


Source:
Mouse

Purification method:
Protein G purification

Isotype:
IgG1

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
low density lipoprotein receptor

Calculated molecular weight:
95 kDa

Observed molecular weight:
120 kDa, 160 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
LDLR

Synonyms
FH, FHC, LDL receptor, LDLR
Background

LDLR (low density lipoprotein receptor) is a member of the LDL receptor gene family and is involved in receptor-mediated endocytosis of specific ligands. The LDLR is a cell surface glycoprotein that scavenges LDL from the blood and regulates plasma LDL cholesterol. The cytoplasmic domain of the LDL receptor is necessary for the receptor to cluster in coated pits, which promotes the rapid endocytosis of bound LDL. The protein is highly glycosylated through N- and O-linkages and thus migrates at 100 to 160 kDa bands on SDS-PAGE.


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