LRP2-Specific Antibody 2 Publications

Rabbit Polyclonal| Catalog number: 19700-1-AP

  • Print page
  • Download PDF

Be the first to review this product


-_-

Freight/Packing

Con: 48 μg/150 μl

Choose size:

Please visit your regions distributor:


Species specificity:
human, mouse, rat

Positive WB detected in:
HEK-293 cells, human brain tissue, human placenta tissue

Positive IHC detected in:
human kidney tissue

Positive FC detected in:
HEK-293 cells

Recommended dilution:
WB : 1:200-1:1000
IHC : 1:100-1:400

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Immunogen:
Peptide

Full name:
low density lipoprotein-related protein 2

Calculated molecular weight:
522 kDa

Observed molecular weight:
280 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
LRP2

Synonyms
DBS, Fx1a, Glycoprotein 330, gp330, LRP 2, LRP2, Megalin
Background

LRP2, also named as gp330 and Megalin, belongs to the LDLR family. It acts together with cubilin to mediate HDL endocytosis. LRP2 may participate in regulation of parathyroid-hormone and para-thyroid-hormone-related protein release. Defects in LRP2 are the cause of Donnai-Barrow syndrome (DBS). This antibody is specific to LRP2 and detects endogenous LRP2 with an apparent molecular weight 280 kDa, which is smaller than the predicted molecular weight (522 kDa) and probably represent a proteolytic fragment of the large glycoprotein (PMID: 16638803; 8483924).


Back
to top