LY96/MD2 Antibody 0 Publications

Rabbit Polyclonal| Catalog number: 11784-1-AP

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Freight/Packing

Con: 20 μg/150 μl

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Species specificity:
human

Positive WB detected in:
U-937 cells

Positive IHC detected in:
human kidney tissue

Recommended dilution:
WB : 1:500-1:1000
IHC : 1:20-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
lymphocyte antigen 96

Calculated molecular weight:
160aa,18 kDa

Observed molecular weight:
20 kDa and 30 kDa and 35 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
LY96

Synonyms
ESOP 1, ESOP1, Ly 96, LY96, lymphocyte antigen 96, MD 2, MD2, Protein MD 2
Background

LY96, also named as ESOP1 or MD 2, is a small secreted glycoprotein that can bind to both the hydrophobic portion of LPS and to the extracellular domain of TLR4. The interaction between MD-2 and LPS bridges the two TLR4 molecules and induces the dimerization of LPS-MD-2-TLR4, which forms the structural basis for biological functions of TLR4/MD-2 complex. Due to its essential role in mediating the interaction between LPS and TLR4, MD-2 has been extensively explored as a therapeutic target for treatment of inflammatory disorders.


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