MBD2 Antibody 0 Publications

Rabbit Polyclonal| Catalog number: 55200-1-AP

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Freight/Packing

Con: 42 μg/150 μl

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Species specificity:
human, rat

Positive WB detected in:
Jurkat cells, A431 cells, HEK-293 cells, human brain tissue

Recommended dilution:
WB : 1:500-1:1000

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Immunogen:
Peptide

Full name:
methyl-CpG binding domain protein 2

Calculated molecular weight:
43 kDa

Observed molecular weight:
43-45 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
MBD2

Synonyms
Demethylase, DKFZp586O0821, DMTase, MBD2, NY CO 41
Background

MBD2, also named as DMTase, binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. MBD2 binds hemi-methylated DNA as well. It recruits histone deacetylases and DNA methyltransferases. MBD2 acts as transcriptional repressor and plays a role in gene silencing. (PMID:9774669) This antibody is specific to MBD2. It recognize isoform1 and isoform2 of MBD2.


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