MFN1 Antibody 13 Publications

Rabbit Polyclonal| Catalog number: 13798-1-AP

Featured Product KD/KO validated

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Con: 45 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
human kidney tissue

Positive IHC detected in:
human lung cancer tissue

Recommended dilution:
WB : 1:500-1:1000
IHC : 1:100-1:400

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
mitofusin 1

Calculated molecular weight:
741aa,84 kDa

Observed molecular weight:
86 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
MFN1

Synonyms
DKFZp762F247, FLJ20693, Fzo homolog, hfzo1, hfzo2, MFN1, mitofusin 1, Transmembrane GTPase MFN1
Background

Mitofusin-1 (MFN1) is a mediator of mitochondrial fusion. This protein and mitofusin 2 are homologs of the Drosophila protein fuzzy onion (Fzo). Mitofusins are large predicted GTPases located in outer mitochondrial membrane. They are essential for outer membrane fusion by interacting with each other to facilitate mitochondrial targeting. The mitofusins are the first known protein mediator of mitochondrial fusion, and mediate developmentally regulated post-meiotic fusion of mitochondria.Mfn1 is required on adjacent mitochondria to mediate fusion via interactions of a heptad repeat region that mediates oligomerization of the protein(PMID:16892085).


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