MSH2 Antibody 5 Publications

Rabbit Polyclonal| Catalog number: 15520-1-AP

Featured Product KD/KO validated

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Freight/Packing

Con: 35 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
HeLa cells,A2780 cells

Positive IP detected in:
HeLa cells

Positive IHC detected in:
human colon cancer tissue, human colon cancer tissue, human tonsil tissue

Positive IF detected in:
Hela cells

Positive FC detected in:
HeLa cells

Recommended dilution:
WB : 1:1000-1:4000
IP : 0.5-4.0 ug for IP and 1:500-1:1000 for WB
IHC : 1:20-1:200
IF : 1:10-1:100

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli)

Calculated molecular weight:
105 kDa

Observed molecular weight:
100 kDa-105 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
MSH2

Synonyms
COCA1, FCC1, hMSH2, HNPCC, HNPCC1, LCFS2, MSH2, MutS protein homolog 2
Background

MSH2, named for its homologous to the E.coli MutS gene, takes part in DNA mismatch repair(MMR) to maintain the stability of DNA. MSH2 contains a helix-turn-helix domain, which responds for binding to DNA. Also, MSH2 has a direct role in mutation avoidance and micro-satellite stability in cell.


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