MVP/LRP Antibody 3 Publications

Rabbit Polyclonal| Catalog number: 16478-1-AP

Featured Product KD/KO validated

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Freight/Packing

Con: 41 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
SH-SY5Y cells, A549 cells, HEK-293 cells, human brain tissue, mouse lung tissue, rat lung tissue

Positive IP detected in:
mouse lung tissue

Positive IHC detected in:
human breast cancer tissue, human lung cancer tissue, human kidney tissue, human testis tissue, human skin tissue

Positive IF detected in:
HepG2 cells

Recommended dilution:
WB : 1:500-1:2000
IP : 0.5-4.0 ug for IP and 1:500-1:1000 for WB
IHC : 1:50-1:500
IF : 1:10-1:100

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
major vault protein

Calculated molecular weight:
893aa,99 kDa

Observed molecular weight:
99-104 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
MVP

Synonyms
LRP, major vault protein, MVP, VAULT1
Background

Vaults are the largest cellular ribonuclear protein complexes with a hollow barrel-like structure, and have been associated with the MDR phenotype. Major vault protein (MVP) is the main component of vaults and is presumed to be involved in MDR. MVP is identical with the human lung resistance protein (LRP), known to be overexpressed in multiple chemotherapy resistance models [PMID:23083532]. MVP has been associated to resistance to radiotherapy [4], probably due to its role in preventing apoptosis by inhibiting the COP-1/p53 axis [PMID: 12894554, 15994960].


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