MYH6 Antibody 3 Publications

Rabbit Polyclonal| Catalog number: 22281-1-AP

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Freight/Packing

Con: 65 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
rat heart tissue

Positive IHC detected in:
human heart tissue, human heart tissue, mouse heart tissue

Positive IF detected in:
mouse heart tissue

Recommended dilution:
WB : 1:2000-1:20000
IHC : 1:20-1:200
IF : 1:50-1:500

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Immunogen:
Peptide

Full name:
myosin, heavy chain 6, cardiac muscle, alpha

Calculated molecular weight:
224 kDa

Observed molecular weight:
200-220 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
MYH6

Synonyms
alpha MHC, ASD3, MYH6, MYHC, MyHC alpha, MYHCA, Myosin 6, Myosin heavy chain 6
Background

MYH6 encodes the alpha-cardiac myosin heavy chain (aMHC) which is a major contractile protein exclusively expressed in the myocardium of the heart. Expression of MYH6 is down-regulated in cardiac myopathy and failing hearts. Defects in MYH6 lead to congenital heart disease (CHD), and a spectrum of phenotypes ranging from hypertrophic cardiomyopathy (HCM) and dilated cardiomyopathy (DCM). (15737621, 20656787)


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