NFKB2 Antibody 3 Publications

Rabbit Polyclonal| Catalog number: 10409-2-AP

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Con: 47 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
multi-cells, HeLa cells

Positive IP detected in:
K-562 cells

Positive IHC detected in:
human pancreas cancer tissue, human liver cancer tissue

Positive IF detected in:
HeLa cells

Recommended dilution:
WB : N/A
IP : 0.5-4.0 ug for IP and 1:500-1:1000 for WB
IHC : 1:20-1:200
IF : 1:10-1:100

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)

Calculated molecular weight:
103 kDa

Observed molecular weight:
103 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
NFKB2

Synonyms
DNA binding factor KBF2, H2TF1, LYT 10, LYT10, NFKB2, NFKB2,p100, NFKB2,p52,p100, Oncogene Lyt 10, p100, p52
Background

NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. NFKB2 appears to have dual functions such as cytoplasmic retention of attached NF-kappa-B proteins by p100 and generation of p52 by a cotranslational processing. The proteasome-mediated process ensures the production of both p52 and p100 and preserves their independent function. P52 binds to the kappa-B consensus sequence 5'-GGRNNYYCC-3', located in the enhancer region of genes involved in immune response and acute phase reactions. P52 and p100 are respectively the minor and major form; the processing of p100 being relatively poor. Isoform p49 is a subunit of the NF-kappa-B protein complex, which stimulates the HIV enhancer in synergy with p65. This antibody is a rabbit polyclonal antibody raised against residues near the C terminus of human NFKB2.


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