NOD2 Polyclonal antibody
NOD2 Polyclonal Antibody for ELISA
Host / Isotype
Rabbit / IgG
Reactivity
human, mouse and More (2)
Applications
WB, IP, IHC, IF, ELISA
Conjugate
Unconjugated
Cat no : 20980-1-AP
Synonyms
Validation Data Gallery
Tested Applications
Recommended dilution
| Application | Dilution |
|---|---|
| Sample-dependent, check data in validation data gallery | |
Published Applications
| KD/KO | See 1 publications below |
| WB | See 11 publications below |
| IHC | See 6 publications below |
| IF | See 5 publications below |
| IP | See 1 publications below |
Product Information
20980-1-AP targets NOD2 in WB, IP, IHC, IF, ELISA applications and shows reactivity with human, mouse samples.
| Tested Reactivity | human, mouse |
| Cited Reactivity | bovine, human, mouse, rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide |
| Full Name | nucleotide-binding oligomerization domain containing 2 |
| Calculated molecular weight | 115 kDa |
| GenBank accession number | NM_022162 |
| Gene symbol | NOD2 |
| Gene ID (NCBI) | 64127 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Antigen affinity purification |
| Storage Buffer | PBS with 0.02% sodium azide and 50% glycerol pH 7.3. |
| Storage Conditions | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
Background Information
NOD2, also named as CARD15 and IBD1, induces NF-kappa-B via RICK (CARDIAK, RIP2) and IKK-gamma. It confers responsiveness to intracellular bacterial lipopolysaccharides (LPS). Defects in NOD2 are the cause of Blau syndrome (BS). Defects in NOD2 are a cause of susceptibility to Crohn disease (CD). Defects in NOD2 are a cause of susceptibility to ulcerative colitis. Defects in NOD2 are the cause of early-onset sarcoidosis (EOS). The antibody is specific to NOD2.
Publications
| Species | Application | Title |
|---|---|---|
Cell Death Dis NOD2 inhibits tumorigenesis and increases chemosensitivity of hepatocellular carcinoma by targeting AMPK pathway.
| ||
Vet Immunol Immunopathol 17β-Estradiol and progesterone decrease MDP induced NOD2 expression in bovine mammary epithelial cells. | ||
Neurosci Lett NOD2-RIP2 contributes to the inflammatory responses of mice in vivo to Streptococcus pneumoniae. | ||
J Oral Pathol Med The synergistic effect of NOD2 and TLR4 on the activation of autophagy in human submandibular gland inflammation. | ||
Biochem Biophys Res Commun NOD2 promotes endothelial-to-mesenchymal transition of glomerular endothelial cells via MEK/ERK signaling pathway in diabetic nephropathy. | ||
Cell Physiol Biochem NOD2 Deficiency Protects against Cardiac Remodeling after Myocardial Infarction in Mice. |
