NOD2 Polyclonal antibody

NOD2 Polyclonal Antibody for ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse and More (2)

Applications

WB, IP, IHC, IF, ELISA

Conjugate

Unconjugated

Cat no : 20980-1-AP

Synonyms

ACUG, BLAU, CARD15, CD, CLR16.3, IBD1, NLRC2, NOD2, NOD2B, PSORAS1



Tested Applications

Recommended dilution

ApplicationDilution
Sample-dependent, check data in validation data gallery

Product Information

20980-1-AP targets NOD2 in WB, IP, IHC, IF, ELISA applications and shows reactivity with human, mouse samples.

Tested Reactivity human, mouse
Cited Reactivity cow, human, mouse, rat
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen Peptide
Full Name nucleotide-binding oligomerization domain containing 2
Calculated molecular weight 115 kDa
GenBank accession numberNM_022162
Gene symbol NOD2
Gene ID (NCBI) 64127
Conjugate Unconjugated
Form Liquid
Purification Method Antigen affinity purification
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

Background Information

NOD2, also named as CARD15 and IBD1, induces NF-kappa-B via RICK (CARDIAK, RIP2) and IKK-gamma. It confers responsiveness to intracellular bacterial lipopolysaccharides (LPS). Defects in NOD2 are the cause of Blau syndrome (BS). Defects in NOD2 are a cause of susceptibility to Crohn disease (CD). Defects in NOD2 are a cause of susceptibility to ulcerative colitis. Defects in NOD2 are the cause of early-onset sarcoidosis (EOS). The antibody is specific to NOD2.

Publications

SpeciesApplicationTitle
human,mouseWB,IF,IP

Cell Death Dis

NOD2 inhibits tumorigenesis and increases chemosensitivity of hepatocellular carcinoma by targeting AMPK pathway.

Authors - Xiaomin Ma
  • KO Validated
cowWB

Vet Immunol Immunopathol

17β-Estradiol and progesterone decrease MDP induced NOD2 expression in bovine mammary epithelial cells.

Authors - Dan-Dan Xu
mouseWB

Neurosci Lett

NOD2-RIP2 contributes to the inflammatory responses of mice in vivo to Streptococcus pneumoniae.

Authors - Yuan Zheng
humanIHC,IF

J Oral Pathol Med

The synergistic effect of NOD2 and TLR4 on the activation of autophagy in human submandibular gland inflammation.

Authors - Jiajie Li
humanWB,IHC,IF

Biochem Biophys Res Commun

NOD2 promotes endothelial-to-mesenchymal transition of glomerular endothelial cells via MEK/ERK signaling pathway in diabetic nephropathy.

Authors - Jin Shang
mouseWB,IHC

Cell Physiol Biochem

NOD2 Deficiency Protects against Cardiac Remodeling after Myocardial Infarction in Mice.

Authors - Xiang Li