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NOD2 Antibody 12 Publications

Rabbit Polyclonal| Catalog number: 20980-1-AP

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Con: 53 μg/150 μl

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Tested Applications

Applications:
WB, IP, IHC, IF, ELISA
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Species specificity:
human, mouse, cow, rat
Recommended dilution:
Sample-dependent, check data in Validation tab

Product Information

Source:
Rabbit
Purification method:
Antigen affinity purification
Isotype:
IgG
Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information

Immunogen:
Peptide
Full name:
nucleotide-binding oligomerization domain containing 2
Calculated molecular weight:
115 kDa
Observed molecular weight:
GenBank accession number:
NM_022162
Gene ID (NCBI):
64127
Gene symbol
NOD2
Synonyms
ACUG, BLAU, CARD15, CD, CLR16.3, IBD1, NLRC2, NOD2, NOD2B, PSORAS1

Background

NOD2, also named as CARD15 and IBD1, induces NF-kappa-B via RICK (CARDIAK, RIP2) and IKK-gamma. It confers responsiveness to intracellular bacterial lipopolysaccharides (LPS). Defects in NOD2 are the cause of Blau syndrome (BS). Defects in NOD2 are a cause of susceptibility to Crohn disease (CD). Defects in NOD2 are a cause of susceptibility to ulcerative colitis. Defects in NOD2 are the cause of early-onset sarcoidosis (EOS). The antibody is specific to NOD2.


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