ORAI1 Antibody 14 Publications

Rabbit Polyclonal| Catalog number: 13130-1-AP

Featured Product KD/KO validated

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Freight/Packing

Con: 40 μg/150 μl

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Species specificity:
human, mouse, rat, zebrafish

Positive WB detected in:
Jurkat cells, A375 cells, Jurkat cells, MCF-7 cells, mouse ovary tissue, mouse spleen tissue, PC-3 cells

Positive IF detected in:
HEK-293 cells

Recommended dilution:
WB : 1:500-1:1000
IF : 1:10-1:100

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
ORAI calcium release-activated calcium modulator 1

Calculated molecular weight:
301aa,33 kDa

Observed molecular weight:
45-47 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
ORAI1

Synonyms
CRACM1, FLJ14466, ORAI1, ORAI1 L1, ORAI1 L2, Orail L2, ORAT1, Protein orai 1, TMEM142A, Transmembrane protein 142A
Background

Store-operated calcium channels (SOCs) play essential functions in various physiological processes. Orai1 (also named CRACM1) is a critical molecular component of SOCs. Orai1 protein is a 32-55 kDa plasma membrane protein with 4 transmembrane domains. Human patients with a severe combinaed immunodeficiency (SCID) syndrome possess point mutations in Orai1 gene.


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