PPP3CA-specific Antibody 0 Publications

Rabbit Polyclonal| Catalog number: 55147-1-AP

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Freight/Packing

Con: 33 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
mouse brain tissue, mouse pancreas tissue

Positive IHC detected in:
human heart tissue, human brain tissue, human heart tissue

Recommended dilution:
WB : 1:500-1:1000
IHC : 1:20-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Immunogen:
Peptide

Full name:
protein phosphatase 3 (formerly 2B), catalytic subunit, alpha isoform

Calculated molecular weight:
59 kDa

Observed molecular weight:
59 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
PPP3CA

Synonyms
Calcineurin A alpha, CALN, CALNA, CALNA1, CAM PRP catalytic subunit, CCN1, CNA, CNA1, PPP2B, PPP3CA
Background

PPP3CA, also called calcineurin Aα, is the only serine/threonine protein phosphatase under the control of Ca2+/calmodulin, and plays a critical role in the coupling of Ca2+ signals to cellular responses. Ca2+ signaling plays a central role in hypertrophic growth of cardiac and skeletal muscle in response to mechanical load and a variety of signals. Therefore, PPP3CA plays an important role in muscle differentiation, especially in muscle fiber type conversion. It is also involved in osteoclast regulation, regulating bone formation through an effect on osteoblast differentiation. This antibody is specific to PPP3CA.


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