PRKAR2A Antibody 0 Publications

Rabbit Polyclonal| Catalog number: 10142-2-AP

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Freight/Packing

Con: 47 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
K-562 cells, HeLa cells, human testis tissue, K-562 cells, MCF-7 cells, mouse testis tissue, PC-3 cells

Positive IP detected in:
HeLa cells, K-562 cells

Positive IF detected in:
HeLa cells, HepG2 cells, MCF-7 cells

Recommended dilution:
WB : 1:500-1:2000
IP : 0.5-4.0 ug for IP and 1:500-1:2000 for WB
IF : 1:10-1:100

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
protein kinase, cAMP-dependent, regulatory, type II, alpha

Calculated molecular weight:
43 kDa

Observed molecular weight:
46-52 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
PRKAR2A

Synonyms
PKR2, PRKAR2, PRKAR2A
Background

The effects of cAMP in most tissues and cell types are mainly modulated via protein kinase A, a heterotetrameric protein complex consisting of two regulatory and two catalytic subunits. The regulatory subunit of cAMP-dependent protein kinase (PRKAR2A) is one of the regulatory subunits and the gene is located on chromosome region 3p21.3-p21.2. The expression of PRKAR2A is tightly regulated during spermatogenesis, a significant increase in expression of this gene was also found in the human myometrium during pregnancy. This antibody got two bands about 45 kDa and 50-55 kDa in western blotting, and the 50-55kDa may be caused by phosphorylation.


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