RBP4 Antibody 4 Publications

Rabbit Polyclonal| Catalog number: 11774-1-AP

Featured Product KD/KO validated

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Freight/Packing

Con: 30 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
human plasma tissue, human liver tissue, mouse liver tissue, rat liver tissue

Positive IHC detected in:
human liver cancer tissue, human liver cancer tissue, mouse liver tissue

Recommended dilution:
WB : 1:500-1:2000
IHC : 1:20-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
retinol binding protein 4, plasma

Calculated molecular weight:
201aa,23 kDa

Observed molecular weight:
23 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
RBP4

Synonyms
Plasma retinol binding protein, PRBP, RBP, RBP4, Retinol binding protein 4
Background

RBP4 (retinol-binding protein 4) is a carrier protein that transports vitamin A (retinol) from the liver to the peripheral tissues. Synthesized primarily by hepatocytes and adipocytes as a 21 kDa non-glycosylated protein, RBP4 is secreted into the circulation as a retinol-RBP4 complex. In plasma the RBP4-retinol complex is bound to transthyretin (TRR), which prevents prevent kidney filtration. Two truncated forms of RBP4, RBP4-L (truncated at Leu-183) and RBP4-LL (truncated at Leu-182 and Leu-183), exist by proteolytic process. RBP4-L and RBP4-LL, which do not bind TTR, are normally excreted into the urine but accumulate in the serum during renal failure. Urinary RBP4 has been reported as marker for glomerular disease. RBP4 also was identified as an adipokine that elevated in some insulin-resistant states. Measurement of serum RBP4 could be used to assess the risk of insulin resistance, type 2 diabetes, obesity, and cardiovascular disease. (18752671, 16034410)


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