S100A11 Antibody 25 Publications

Rabbit Polyclonal| Catalog number: 10237-1-AP

Featured Product KD/KO validated

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Freight/Packing

Con: 69 μg/150 μl

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Species specificity:
human, rat, mouse

Positive WB detected in:
PC-3 cells, BxCOLO 320 cells, DU 145 cells, HEK-293 cells, human heart tissue, human lung tissue, PC-12 cells, SKOV-3 cells, U2OS cells

Positive IP detected in:
PC-3 cells

Positive IHC detected in:
human breast cancer tissue, human colon cancer tissue, mouse liver tissue

Positive FC detected in:
MCF-7 cells

Recommended dilution:
WB : 1:1000-1:4000
IP : 0.5-4.0 ug for IP and 1:500-1:2000 for WB
IHC : 1:50-1:500

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
S100 calcium binding protein A11

Calculated molecular weight:
105aa,12 kDa

Observed molecular weight:
12 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
S100A11

Synonyms
Calgizzarin, MLN 70, MLN70, Protein S100 A11, Protein S100 C, S100A11, S100C
Background

S100A11 (also known as S100C or calziggarin), is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs (PMID: 18694925). S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. First discovered in 1989, S100A11 has since been proposed to have direct biological functions in an assortment of physiological processes such as endo- and exocytosis, regulation of enzyme activity, cell growth and regulation, apoptosis and inflammation (PMID: 15241500). Chromosomal rearrangements and altered expression of S100A11 have been implicated in tumor metastasis. This S100A11 antibody (10237-1-AP) has also been instrumental in investigations into S100A11’s role in the development of brain tumors in tuberous sclerosis complex (TSC) patients (PMID: 20133820).


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