SIAH1 Antibody 0 Publications

Rabbit Polyclonal| Catalog number: 13886-1-AP

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Freight/Packing

Con: 30 μg/150 μl

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Species specificity:
human, mouse

Positive WB detected in:
HeLa cells, A549 cells, COLO 320 cells, HeLa cells, HepG2 cells, Jurkat cells, mouse small intestine tissue

Recommended dilution:
WB : 1:500-1:1000

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
seven in absentia homolog 1 (Drosophila)

Calculated molecular weight:
282aa,31 kDa

Observed molecular weight:
60 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
SIAH1

Synonyms
SIAH1, hSIAH1, Siah 1a, Seven in absentia homolog 1, Siah 1
Background

SIAH1, also named as HUMSIAH, Siah-1a and Siah-1S(21kd), belongs to the SINA (Seven in absentia) family. SIAH1 is known to cause indirect degradation of beta-catenin through formation of a complex with Siah-interacting protein (SIP), Skp1 and Ebi. SIAH1 can form heterodimer or homodimer such as Siah-1*Siah-1(70 or 62kd), Siah-1*Siah-1S(42kd) and Siah-1S*Siah-1S(51-56kd). Importantly, results from in vitro soft agar assay demonstrated that Siah-1S displays a promotion effect on cells tumorigenicity. (PMID:17420721)


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