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TEAD1 Polyclonal antibody

TEAD1 Polyclonal Antibody for WB, ELISA

Host / Isotype

Rabbit / IgG

Reactivity

mouse, human and More (1)

Applications

WB, IF, ELISA

Conjugate

Unconjugated

Cat no : 13283-1-AP

Synonyms

AA, NTEF 1, Protein GT IIC, REF1, TCF 13, TCF13, TEA domain family member 1, TEAD 1, TEAD1, TEF 1, TEF1, Transcription factor 13



Tested Applications

Positive WB detected inBGC-823 cells, A375 cells, C2C12 cells

Recommended dilution

ApplicationDilution
Western Blot (WB)WB : 1:500-1:1500
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

Product Information

13283-1-AP targets TEAD1 in WB, IF, ELISA applications and shows reactivity with mouse, human samples.

Tested Reactivity mouse, human
Cited Reactivityhuman, rat
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen TEAD1 fusion protein Ag4082
Full Name TEA domain family member 1 (SV40 transcriptional enhancer factor)
Calculated Molecular Weight 426 aa, 47, 9 kDa
Observed Molecular Weight 52 kDa
GenBank Accession NumberBC026959
Gene Symbol TEAD1
Gene ID (NCBI) 7003
RRIDAB_2287290
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA.

Background Information

TEAD1 belongs to a protein family that share the TEA/ATTS domain. It acts as a transcriptional factor by binding to the GT-IIC and Sph(I 1 II) enhansons in the simian virus 40 (SV40) enhancer. Also it can modulate SV40 late transcription together with large T antigen. The transcriptional activity of TEAD1 required several regions of the proteins , a TBP-associated factors and a limiting transcriptional intermediary factors. TEAD1 also preforms an essential role in the Hippo signaling pathway. TEAD1 regulates gene expression of YAP1 and WWTR1/TAZ, thus mediating cell proliferation, migration and epithelial mesenchymal transition induction. TEAD is preferentially expressed in skeletal muscle. Lower levels in pancreas, placenta, and heart.

Protocols

Product Specific Protocols
WB protocol for TEAD1 antibody 13283-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols

Publications

SpeciesApplicationTitle
humanWB

Cancer Lett

EGFR/c-myc axis regulates TGFβ/Hippo/Notch pathway via epigenetic silencing miR-524 in gliomas.

Authors - Kai Zhao
humanWB

Cancers (Basel)

WISP2/CCN5 Suppresses Vasculogenic Mimicry through Inhibition of YAP/TAZ Signaling in Breast Cancer Cells.

Authors - Nathalie Ferrand
humanWB

Int J Mol Sci

Role of Clostridium perfringens Enterotoxin on YAP Activation in Colonic Sessile Serrated Adenoma/ Polyps with Dysplasia.

Authors - Rina Fujiwara-Tani
humanWB,IF

Dig Dis Sci

TEA Domain Transcription Factor 1 Inhibits Ferroptosis and Sorafenib Sensitivity of Hepatocellular Carcinoma Cells

Authors - Hongmin Li
humanWB

Biomed Pharmacother

YAP1-TEAD1-Glut1 axis dictates the oncogenic phenotypes of breast cancer cells by modulating glycolysis.

Authors - Chunli Lin
WB

Oncol Rep

YAP is overexpressed in clear cell renal cell carcinoma and its knockdown reduces cell proliferation and induces cell cycle arrest and apoptosis.

Authors - Jian-Jia Cao