Thyroglobulin Monoclonal antibody

Thyroglobulin Monoclonal Antibody for IHC,ELISA

Host / Isotype

Mouse / IgG2a

Reactivity

human

Applications

IHC,ELISA

Conjugate

Unconjugated

CloneNo.

4D3C5

Cat no : 60272-1-Ig

Synonyms

AITD3, TG, TGN, thyroglobulin



Tested Applications

Positive IHC detected inhuman thyroid tissue, human thyroid cancer tissue
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0

Recommended dilution

ApplicationDilution
Immunohistochemistry (IHC)IHC : 1:50-1:500
Sample-dependent, check data in validation data gallery

Published Applications

IHCSee 1 publications below

Product Information

60272-1-Ig targets Thyroglobulin in IHC,ELISA applications and shows reactivity with human samples.

Tested Reactivity human
Cited Reactivity human
Host / Isotype Mouse / IgG2a
Class Monoclonal
Type Antibody
Immunogen Thyroglobulin fusion protein Ag18070
Full Name thyroglobulin
Calculated molecular weight 2768 aa, 305 kDa
GenBank accession numberBC140933
Gene symbol TG
Gene ID (NCBI) 7038
Conjugate Unconjugated
Form Liquid
Purification Method Protein A purification
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

Background Information

Thyroglobulin (Tg) is a glycoprotein homodimer produced predominantly by the thryroid gland. It acts as a substrate for the synthesis of thyroxine and triiodothyronine as well as the storage of the inactive forms of thyroid hormone and iodine. Thyroglobulin is secreted from the endoplasmic reticulum to its site of iodination, and subsequent thyroxine biosynthesis, in the follicular lumen. Mutations in this gene cause thyroid dyshormonogenesis, manifested as goiter, and are associated with moderate to severe congenital hypothyroidism. Polymorphisms in this gene are associated with susceptibility to autoimmune thyroid diseases (AITD) such as Graves disease and Hashimoto thryoiditis.

Protocols

Product Specific Protocols
IHC protocol for Thyroglobulin antibody 60272-1-IgDownload protocol
Standard Protocols
Click here to view our Standard Protocols

Publications

SpeciesApplicationTitle
humanIHC

Cancer Cell Int

Identification of an immune-related signature indicating the dedifferentiation of thyroid cells.

Authors - Xuemin Wang