TRIM63 Antibody 1 Publications

Rabbit Polyclonal| Catalog number: 55456-1-AP

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Con: 100 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
mouse skeletal muscle tissue, mouse heart tissue

Positive IHC detected in:
human heart tissue, human heart tissue, human skeletal muscle tissue, mouse heart tissue, rat brain tissue

Positive IF detected in:
HeLa cells

Recommended dilution:
WB : 1:500-1:1000
IHC : 1:20-1:200
IF : 1:10-1:100

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Immunogen:
Peptide

Full name:
tripartite motif-containing 63

Calculated molecular weight:
40 kDa

Observed molecular weight:
40 kDa,35 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
TRIM63

Synonyms
FLJ32380, IRF, Iris RING finger protein, MuRF 1, MURF1, MURF2, RING finger protein 28, RNF28, SMRZ, TRIM63, tripartite motif containing 63
Background

TRIM63, also named as IRF, MURF1, RNF28 and SMRZ, is E3 ubiquitin ligase. It is regulates proteasomal degradation of cardiac troponin I/TNNI3 and probably of other sarcomeric-associated proteins. TRIM63 may play a role in striated muscle atrophy and hypertrophy by regulating an anti-hypertrophic PKC-mediated signaling pathway. It may regulate the organization of myofibrils through TTN in muscle cells. This antibody is specific to TRIM63.


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